GeneNote is a full-genome database of expression in healthy human tissues. We present the full transcriptome for both known and novel genes.

GeneNote database contains raw data, normalized data and various analyses. The acquisition of genomic expression data was based on high-density DNA micrroarrays (Affymetrix GeneChip HG-U95A-E consisting of 62,839 probe-sets representative of the full human genome repertoire). The expression data was normalized using alternative methods to produce an expression profile for each gene, known as its tissue vector.

For each tissue, tissue specific genes were identified, as well as housekeeping genes, which are uniformly expressed in all tissues. A Tissue Specificity Index (TSI) was calculated for each tissue vector, in order to rank the genes on a scale between fully tissue specific and fully housekeeping. The relationships between tissues were determined by two way clustering according to each gene and tissue expression profiles.

The interpretation of the RNA expression data requires linking between probe sequences and the gene they represent, and acquiring broad biological knowledge regarding each gene's function, biological processes and counterparts. Via the GeneCards , GeneAnnot and GeneLoc projects, such information, known as gene annotation is connected to the expression profiles. Gene annotation is essential for understanding the cellular program and the molecular physiology of an organism. GeneNote genes were linked to their probe-sets and the expression profiles of genes and probe sets are presented.